home *** CD-ROM | disk | FTP | other *** search
- *********************************
- * Dps protein family signatures *
- *********************************
-
- Escherichia coli protein dps [1] is a DNA-binding protein, synthesized during
- prolonged starvation, that seems to protect DNA from oxidative damage. Dps
- binds DNA without any apparent sequence specificity. It is a protein of about
- 19 Kd that associates into a complex of 12 subunits forming two stacked
- hexameric rings.
-
- Proteins similar to dps have been found in other bacteria:
-
- - Antigen TpF1/TyF1 from Treponema pallidum and pertenue.
- - A low-temperature induced protein from Anabaena variabilis.
- - A hypothetical protein encoded in the 5' region of a gene coding for a
- bromoperoxidase, in plasmid pOP2621 of Streptomyces aureofaciens.
-
- All these proteins share a conserved region of about 50 residues in their
- central region. We have developed two signature patterns derived from both
- extremities of that region.
-
- -Consensus pattern: H-W-x(3)-G-x(5)-[LIVM]-H-x-[LIVM]-x-[DE]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Consensus pattern: [DE]-x-[LIVM]-A-E-R-x(3)-L-G-[GA]-x(3)-[AG]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Last update: October 1993 / First entry.
-
- [ 1] Almiron M., Link A.J., Furlong D., Kolter R.
- Genes Dev. 6:2646-2654(1992).
-